Session 10: Poster Session C — ASN Events

Session 10: Poster Session C — ASN Events

Session 10: Poster Session C

Localised control of Torso Receptor Tyrosine Kinase activation in Drosophila terminal patterning (#301)

Michelle A Henstridge

CKI and GSK3 sequentially phosphorylate CaMKKβ (#302)

Matthew T O'Brien

MODE OF INTERACTION OF LC3A AND GABARAP WITH Atg16L1 (#303)

Arvind Chand Ravichandran

Defining the roles of activin receptor (ActRIIB) in the proliferation and migration of human breast cancer cells (#304)

Structural characterisation of the CCN family growth factors (#305)

Looking for biomarkers in platelets of Alzheimer’s disease patients (#306)

Luz Fernanda Yevenes Ugarte

Characterisation of the substrate specificity and active site of Arabidopsis thaliana glycerol 3-phosphate acyltransferase 4 (#307)

Thomas R Brereton

Investigation of ARHGEF7 to stimulate Guanine Nucleotide Exchange of Parkinson’s Disease causative LRRK2 Kinase. (#308)

ROLE OF DYNAMIN 1 MIDDLE DOMAIN SPLICING IN SELF-ASSEMBLY AND ENZYME ACTIVITY (#309)

Michael Collett

Report of Two Active DHDPS in the Moss P. Patens (#310)

Sebastien Desbois

Not different, just better: The adaptive evolution of a key glycolytic enzyme (#311)

Katherine A Donovan

Defining Bruton’s Tyrosine Kinase Signaling Mechanism in B cell Malignancies (#312)

Minglyanna Gaku Surudoi

The LINK to Inhibiting a Promising Anti-Cholera Target (#313)

From Gene Knockout Phenotype to Structure & Function of Aspartate Semialdehyde Dehydrogenase from Staphylococcus aureus (#314)

Rubisco activase forms small active oligomers (#315)

Identification of the determinant of CSK-Homologous Kinase (CHK) important for its tumour suppressor effects (#316)

Exploring Catalytic Promiscuity In The Alkaline Phosphatase Superfamily By Directed Evolution (#317)

Charlotte M Miton

The Catalytic Mechanism of the PA-824 Prodrug-activating F420-Dependent Reductase (DDN) from Mycobacterium tuberculosis (#318)

Ahmed E Mohamed

Biotin protein ligase: a novel anti-TB drug target (#319)

Ashleigh A S Paparella

From Cold to Hot: A Temperature Analysis of the Quaternary Structure of the Enzyme Diaminopimelate Decarboxylase (#320)

Martin G. Peverelli

Structural studies of human α2-antiplasmin (#321)

Transient dimerization of Human MxA results in GTP hydrolysis and an associated power stroke (#322)

Martin L Rennie

Mechanisms regulating ribosome biogenesis by AKT and c-MYC (#323)

Investigating the Antimalarial Drug Targets, PfA-M1 and PfA-M17, using Molecular Dynamics Simulations (#324)

Elucidating the function of the AAA+ protein SKD3, in mammalian mitochondria (#325)

Investigating the immune function of the Drosophila melanogaster MACPF protein Torso-like (#326)

Lauren J Forbes Beadle

Defining the structural and antigenic properties of EBA-175 RIII-V (#327)

Extracellular aggregated SOD1 is toxic to astrocytes. (#328)

A molecular basis for the association of the HLA-DRB1 locus, citrullination and rheumatoid arthritis (#329)

The structural basis for Ly49-m157 specificity (#330)

The tomato defensin TPP3 induces tumour cell lysis through a conserved mechanism involving PIP2 binding and oligomerization (#331)

Interactions of Disulfide-deficient Selenocysteine Analogues of µ-BuIIIB with the Voltage-Gated Sodium Channel Na_V1.3 (#332)

Self assembly of collagen model peptides (#333)

Deepti Mahapatra

Plant defensin, NaD1, and it's lipid binding motif (#334)

The role of disulfide bonds in the structure and activity of chlorotoxin (#335)

Self assembly of protein derived peptides (#336)

Cationic structural grip: an evolutionarily conserved feature of tumourolytic defensins? (#337)

Characterisation of Kiwifruit Proteins to Improve Digestion (#338)

Diversity of conotoxin gene superfamilies in Conus victoriae (#339)

Samuel Robinson

Optimisation and characterisation of cyclic peptides targeting the Grb7 SH2 domain (#340)

Gabrielle Watson

Equilibrium Conformational Ensemble of Intrinsically-Disordered Peptide n16N: Linking Sub-domain Structure and Function in Nacre (#341)

Design, development and validation of galectin-3-specific inhibitors (#342)

Khuchtumur Bum-Erdene

Validation of Antibody-peptide docking in Glide and GOLD (#343)

Ligand Binding Dynamics into the Active Site of MRSA-DHDPS Reveals the Presence of Kinetic and Thermodynamic ‘Hot Spots’ (#344)

Shane E. Gordon

Does the flexible loop of the M17 aminopeptidase from Plasmodium falciparum control entrance to the active site? (#345)

Nikolas Hochheimer

Targeting LRH-1 as a breast cancer treatment (#346)

Stephanie Kusumo

Structurally guided small molecule targeting of the Insulin and Type 1 Insulin-like Growth Factor Receptors. (#347)

Callum Lawrence

Development of inhibitors of Plasmodium falciparum apical membrane antigen 1 based on fragment screening (#348)

The Role of the Tyr131-Tyr132 π-stackand Trp78 Hydrophobic Gate Residue in theAllosteric Inhibition of Vitis vinifera (#349)

buy one, get two free: targeting three malarial aminopeptidases with a single designed inhibitor (#350)

Defining the Molecular Determinants of Allosteric Inhibition of a Promising Antimicrobial Target (#351)

Probing the inhibitor selectivity pocket of class II PI3KC2β (#352)

Krithika Sundaram

A Novel Approach to Leukaemia Treatment : 14-3-3ζ destabilization (#353)

Design, Synthesis and Binding Studies of Cyclic Peptide Inhibitors of SPSB2-iNOS Interactions as a New Class of Anti-infectives (#354)

Ancestral reconstruction to unnatural Amino acids – Enhancing protein capabilities (#355)

William H Zhang

A Probabilistic Approach to In Silico Protein Design (#356)

Elaboration of benzoylurea inhibitors targeting pro‑survival Bcl‑x_L (#357)

Origin of substrate and cofactor specificity in F₄₂₀H₂-Dependent Reductases (FDRs) from Mycobacteria (#358)

NMR studies of ligand interactions with apical membrane antigen 1 (AMA1), a target for antimalarial drug development (#359)

Krishnarjuna Bankala

Investigating substrate specificity and cooperation between mitochondrial proteases LONM and CLPXP (#360)

Structural Insights into Bak Activation and Oligomerisation (#361)

DPV022, a novel viral Bcl-2 protein (#362)

Cycles of disruption and repair underlie the evolution of new enzyme function (#363)

Eleanor Campbell

Mechanistic aspects of evolution in the amino acid-binding protein family: reconstruction of promiscuous ancestral proteins (#364)

Benjamin E Clifton

Unravelling the Structural and Functional Characterisation of the Cold-Inducible RNA-Binding Protein CIRP and its Application to Enhanced Recombinant Protein Production (#365)

Tilbe Creigh-Pulatmen

A Physiochemical Characterisation of Caprine Beta-Lactoglobulin (#366)

Jennifer Crowther

Measuring Intracellular Nucleotides and Changes in AMPK Phosphorylation in Response to Small Molecules (#367)

Evolution of new oligomeric structure in response to heat stress (#368)

Structural Studies of Alzheimer’s Disease Amyloid Precursor Protein – Towards Understanding Its Mechanism of Signalling (#369)

Characterisation of CDC-membrane interaction via a metallophosphatase, Alr1329. (#370)

Src protein tyrosine kinase is important for survival of cultured primary cortical neurons (#371)

Md Ashfaqul Hoque

Structural and functional consequences of phosphorylation on the small heat-shock protein Hsp27 (#372)

Blagojce Jovcevski

Functionalized amyloid fibrils- Novel bionanomaterials (#373)

New tags for paramagnetic NMR spectroscopy (#374)

Towards a structural understanding of the cell polarity regulator and tumour suppressor protein, Scribble (#375)

Variola Viral F1L inhibition acts through unique partners. (#376)

Lectin-like bacteriocin from Pseudomonas aeruginosa targets lipopolysaccharide through the rare deoxyhexose D-rhamnose (#377)

Laura McCaughey

Engineering enzymes to probe novel antibiotic targets within sialic acid catabolism (#378)

Conformational changes in FABP1 on ligand binding: A mechanism for intracellular drug delivery? (#379)

Structural and functional characterization of Rubisco from Red Seaweed (Porphyra) and Green Seaweed (Ulva) (#380)

Nivaskumar Ramaswamy

Exploring the structure of viral fusion glycoprotein gp64 by Small Angle X-ray Scattering (SAXS) and preliminary X-ray Crystallography (#381)

Abdullah Sarrac

In search fora novel antibiotic targeting Neisseria meningitidis DsbD (#382)

Insights into the molecular mechanism of Smc-based condensin by structural studies (#383)

Characterising the PlyA dimer and its function in initiating pleurotolysin pore formation (#384)

Bradley A Spicer

Structural and functional characterisation of molinate hydrolase provides insight into the newest amidohydrolase superfamily subtype (#385)

Characterisation of a ClpS homolog in Plasmodium falciparum (#386)

LIGAND BINDING PATHWAYS IN FATTY ACID-BINDING PROTEINS (#387)

Using TALEN mediated gene disruption to study the role of mitochondrial proteins with unknown function. (#388)

Rochelle Tixeira

Using hydrophobins to develop targeted drug delivery vehicle (#389)

Jennifer I-Chun Lai

A study of the proteomic response of bat (Pteropus alecto) kidney cells to a viral mimic using iTRAQ and DIGE. (#390)

Membrane structures of eye lens protein fragments (#391)