Soft hybrid bionanomaterials comprising proteins and synthetic polymers provide an attractive opportunity to increase the diversity of chemical milieux encountered by protein-based components. This is because the chemical construction of a surface-bound polymer corona enables the biomolecules to be utilised in a range of dielectric mediums, and potentially, in both the solid and the liquid phase. To this end, I describe a new integrated approach based on a generic strategy in which nanoscale building blocks are used to produce functional protein-polymer surfactant nanohybrids with a diverse range of properties. The approach involves systematically tuning protein-protein interactions via chemical modifications of the biomolecule surface to produce highly adaptable protein-polymer surfactant nanoconstructs that can be either dehydrated to produce functional solvent-free nanoliquids^1,2, dispersed in aqueous solutions to generate artificial membrane binding proteins with tuneable cell affinities, or spontaneously self-assembled to yield hierarchically ordered, catalytically active soft membranes³. Remarkably, this new class of soft hybrid bionanomaterials retains near-native protein structures that are catalytically active, and exhibit extreme thermophilic behaviour.