Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI) and Alzheimer’s disease (AD) — ASN Events
  1. Schedule
  2. Session 12: Poster Session D - Including Happy Hour & Trade Display
  3. Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI) and Alzheimer’s disease (AD)

Analyses of the similarity and difference of global gene expression profiles in cortex regions of three neurodegenerative diseases: sporadic Creutzfeldt-Jakob disease (sCJD), fatal familial insomnia (FFI) and Alzheimer’s disease (AD) (#404)

Chan Tian 1 , Di Liu 2 , Wei Xiang 3 , Hans Kretzschmar 4 , Xiaoping Dong 1
  1. State Key Laboratory for Infectious Disease Prevention and Control, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
  2. Network Information Center, Institute of Microbiology, Chinese Academy of Sciences., Beijing, China
  3. Institute of Biochemistry, Friedrich-Alexander-University of Erlangen-Nürnberg, Erlangen, Germany
  4. Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany
Neurodegenerative disease is a general designation for the disorders that progressive loss of structure or function and final death of neurons, including Alzheimer’s, Parkinson’s, Huntington’s and prion diseases, etc. In this study, we comparatively analyzed 21 individual microarray datasets of the cortex tissues from 11 sporadic Creutzfeldt-Jakob disease (sCJD), 3 fatal familial insomnia (FFI), 3 Alzheimer’s disease (AD) and 4 normal controls. After normalization, a collection of 730 differently expressed sets (DESets) were obtained by comparison of the data of three diseases with their original controls. Principal component analysis (PCA) showed a background-related distribution within the groups of FFI, AD and normal control, but two apparently different subgroups within the group of sCJD were observed. Review of the clinical materials of 11 sCJD patients identified the difference in brain PrPSc deposits between two subgroups. Hierarchical cluster analysis illustrated the relatively independent clusters of normal controls, FFIs, six sCJD cases (subgroup 1) with more PrPSc deposits, respectively, while an overlapped cluster of five cases of sCJD2 (subgroup 2) with less PrPSc deposits and AD patients. Despite of presences of special gene expressions, many common features were found among those neurodegenerative diseases. The most commonly changed biological processes (BPs) were signal transduction, synaptic transmission and neuropeptide signaling pathway. The most commonly changed pathways were MAPK signaling pathway, Parkinson's disease, oxidative phosphorylation.Our data here provide the similarity and difference in global gene expressions among the patients with sCJD, FFI and AD, which may help to understand the common mechanism of neurodegenerative diseases.